The government outlined a sweeping plan Wednesday to make vaccines for COVID-19 available for free to all Americans, assuming a safe and effective shot is developed, even as top health officials faced questions about political interference with virus information reaching the public.

In a report to Congress and an accompanying “playbook” for states and localities, federal health agencies and the Defense Department sketched out complex plans for a vaccination campaign to begin gradually in January or even late this year, eventually ramping up to reach any American who wants a shot. The Pentagon would be involved with the distribution of vaccines, but civilian health workers would be the ones giving shots.

But the whole enterprise is facing public skepticism. Only about half of Americans said they’d get vaccinated in an Associated Press-NORC poll taken in May.

Centers for Disease Control and Prevention Director Dr. Robert Redfield discussed the plan before Senate lawmakers Wednesday amid concerns that his agency had been pushed to revise several scientific assessments of the virus by Trump appointees.

Redfield told members of the Senate’s Appropriations Committee that the “scientific integrity” of the CDC’s output “has not been compromised and it will not be compromised under my watch.”

Last week news outlets reported that Michael Caputo, a Health and Human Services Department political appointee, tried to gain editorial control over CDC’s flagship weekly scientific report. In a separate online video last week, Caputo reportedly accused CDC scientists of conspiring against President Donald Trump’s reelection.

“It deeply saddens me that those false accusations were made,” Redfield told Senate lawmakers.

Sen. Patty Murray of Washington, the committee’s top Democrat, said political interference had damaged public trust in the government’s health information .

“The Trump administration needs to leave the science to the scientists immediately,” Murray said.

As for the planned vaccine campaign, the CDC playbook for states says it is “much larger in scope and complexity than seasonal influenza or other previous outbreak-related vaccination responses.” Redfield said the his agency will be working with state health officials to execute the vaccination plan in coming days.

Although President Donald Trump asserted Tuesday in an ABC News town hall that a vaccine could be three to four weeks away, officials made it clear to reporters on a call Wednesday that widespread availability would take months.

Among the highlights of the plan:

— For most vaccines, people will need two doses, 21 to 28 days apart. Double-dose vaccines will have to come from the same drugmaker. There could be several vaccines from different manufacturers approved and available.

— Vaccination of the U.S. population won’t be a sprint but a marathon. Initially there may be a limited supply of vaccines, and the focus will be on protecting health workers, other essential employees, and people in vulnerable groups. “Early in (the) COVID-19 vaccination program there may be a limited supply of vaccine and vaccine efforts may focus on those critical to the response, providing direct care and maintaining societal functions, as well as those at highest risk for developing severe illness,” Redfield said. A second and third phase would expand vaccination to the entire population.

— The vaccine itself will be free of charge, thanks to billions of dollars in taxpayer funding approved by Congress and allocated by the Trump administration. The goal is that patients won’t be separately charged for administration of their shots, and officials say they are working to ensure that’s the case for all Medicare recipients and uninsured people as well those covered by insurance at their jobs.

— States and local communities will need to devise precise plans for receiving and locally distributing vaccines, some of which will require special handling such as refrigeration or freezing. States and cities have a month to submit plans.

— A massive information technology effort will be needed to track who is getting which vaccines and when, and the key challenge involves getting multiple public and private databases to link with each other.

Some of the broad components of the federal plan have already been discussed, but Wednesday’s reports attempt to put the key details into a comprehensive framework. Distribution is under the umbrella of Operation Warp Speed, a White House-backed initiative to have vaccines ready to ship in 24 hours from when a version is given emergency use approval by the Food and Drug Administration. Several formulations are undergoing final trials.

However, public skepticism remains. Of the Americans who said in the May AP poll that they wouldn’t get vaccinated, the overwhelming majority said they were worried about safety. To effectively protect the nation from the coronavirus, experts say 70% to 90% of Americans must either be vaccinated or have their own immunity from fighting off COVID-19.

Since the poll, questions have only mounted about whether the government is trying to rush treatments and vaccines to help President Donald Trump’s reelection chances.

Before the Republican National Convention in August, the FDA granted authorization for treatment of COVID-19 patients with plasma from people who have recovered, even though some government scientists were not convinced the clinical evidence was sufficiently strong.

As public confidence in core health agencies has taken a beating, Trump administration officials have been forced to play defense.

“We are working closely with our state and local public health partners … to ensure that Americans can receive the vaccine as soon as possible and vaccinate with confidence,” HHS Secretary Alex Azar said in a statement Wednesday. “Americans should know that the vaccine development process is being driven completely by science and the data.”

That could be a tough sell. In the AP poll, 1 in 5 Americans said they would not get a coronavirus vaccine, and 31% said they were unsure.

Uncertainty is also an issue for the hundreds of federal health care and military officials working on the vaccination program. For example, such basics as the effectiveness of the eventual vaccines are still unknown. The FDA has set a threshold of 50% effectiveness for approving a COVID-19 vaccine.

“We’re dealing in a world of great uncertainty,” said Paul Mango, a top HHS official working on the vaccine plan.

(AP)