More evidence is emerging that far more New Yorkers have had the coronavirus than the number confirmed by lab tests, officials said Thursday, offering insight that could help authorities decide how and how quickly to let people stop isolating from friends and return to work.

Blood samples collected from about 3,000 people indicated that nearly 14% had developed antibodies to fight a coronavirus infection, Gov. Andrew Cuomo said at his daily news briefing.

In New York City, the epicenter of the pandemic in the U.S., 21% of the people tested had antibodies.

It’s not know yet how much protection antibodies provide or how long that immunity might last, and Cuomo cautioned that the data was preliminary. The sample of people tested was small. Participants were hastily recruited at shopping centers and grocery stores, meaning they were healthy enough to be out in public.

But the governor said knowing how many people have antibodies — and who might possibly be immune to the virus — could potentially help set policy on when to reopen parts of the state.

“We’ll have a larger and larger sample. But I want to see snapshots of what is happening with that rate. Is it going up, is it flat, is it down? And it can really give us data to make decisions,” Cuomo said.

Earlier Thursday, New York City’s health commissioner said as many as 1 million people in New York City may have been exposed to the coronavirus.

Across the country, scientists are rolling out blood tests that look for antibodies, proteins that the immune system makes to fight off infection. They don’t detect active infection like the tests for the currently sick. They’re intended to tell who had previously been infected whether they knew it or not.

The New York study is the latest in a small wave of early attempts to try to better determine how widespread infections have been in certain geographic areas. A study in Santa Clara County, California, put the figure at somewhere around 3% to 4%. Another California study, in Los Angeles County, came up with roughly the same percentage.

“I think we are beginning to get interesting little rays of light” into how widespread infections have been, but larger and more rigorous studies will be needed to get a better picture, said Stephen Morse, a Columbia University expert on the spread of diseases.

At least 263,000 people in New York state, including about 142,000 people in New York City, have tested positive for the coronavirus, but city Health Commissioner Dr. Oxiris Barbot called those numbers “the tip of the iceberg.”

She noted the city is still telling people who suspect they have the virus but aren’t seriously ill that they don’t need to seek a test, so the true number of people infected is unknown.

“It wouldn’t surprise me if, at this point in time, we have probably close to 1 million New Yorkers who have been exposed to COVID-19,” she said.

Another 438 people were killed by the virus in the state Wednesday, bringing its total death toll to more than 15,700. That number doesn’t include more than 5,100 other deaths in New York City that were believed to be caused by the virus but haven’t been confirmed by a lab test.

More than 15,000 people remain hospitalized statewide, with nearly 1,400 new patients admitted each day over the past few days.

New York’s attempts to learn how many people have virus antibodies are driven by the desire to know if the region is closer to achieving herd immunity, a state in which so many people have developed defenses against the infection that it becomes hard for the virus to spread.

But such tests need to be done with random sampling, ensuring that the people being tested are representative of geographic, social, racial and other conditions. There are also questions about the accuracy of the blood tests being used. Scientists have found that some of them aren’t reliable enough, with too many false positives and false negatives.

New York’s antibodies survey was done at 40 locations in 19 counties. Relatively few people were found with antibodies, just 3.6%, in areas of upstate New York.

Early on in the pandemic, health officials estimated that as many as half of all people in New York City would get the virus. Mayor Bill de Blasio said that’s still plausible, though the lack of comprehensive, widespread testing makes it difficult to say for sure.

“We are still dealing with the great unknown in the absence of testing. We don’t even 100% know when the first cases emerged in this city, because we didn’t have testing in February,” he said. “We know it was February, but we don’t know how many people got it back then.”

De Blasio said that “in a perfect world” hundreds of thousands of people a day would be tested.

He said the city needs help from the federal government to reach that level of testing but is building testing capacity and should reach 20,000 to 30,000 tests a day by next month.

(AP)