Forum Replies Created
-
AuthorPosts
-
HealthParticipant
Ubiq -“In Saudi Arabia”
“that is one country whose data may or may not be accurate”LOL!!!
Their executions are public events, so what is not accurate? Are you saying that they’re pretending? That there is a lot of crime there?
Obviously you missed my previous post.
Here it is again – the guy obviously lives in the Western World:
“From one of the commenters:”
“I spent 10 years there, and about the only good thing to be said for the place is that it is basically free of violent crime.”HealthParticipantUbiq -“Do you have any data to support, that which has been debunked over and over”
Stop with the liberal lies!
In Saudi Arabia they execute people for crimes, eg. Murder, Drug pushings, etc.
From a UK newspaper online:
“In 2014 they executed 153 criminals.”
From one of the commentors:
“I spent 10 years there, and about the only good thing to be said for the place is that it is basically free of violent crime.”HealthParticipantUbiq -“Now Trump has said police can confiscate guns without first going through court sytem. I assume you agree with this, since you seem to agree with Trump no matter what”
It’s the first time I heard of this. Take away guns from who – regular citizens or criminals?
“Raise age to 21”
I agree with this; but it won’t stop the Killing in the US! The criminals don’t care. And that was my point!
“It is silly because neither countries nor states that have capital punishment have a lower homicde rate. So while it was a good thought, it just isnt true.”
Stop with your deceit! The reason that they don’t is because they don’t have the death penalty in every case of Murder! If they did, the murder rate would drop tremendously!
March 5, 2018 10:52 am at 10:52 am in reply to: Donald Trump Is Bad And Has Popular Support #1480931HealthParticipantiacisrmma: -“shmerel: you would rather have a communist like Sanders?”
Did it ever occur to you that some posters here, believe in Communism?!?
HealthParticipantUbiq -“There is a shooting problem in this country”
Only with the criminals, Not with the gun-carrying law-abiding citizens.
“There has to be a way to improve”
YES!! If anyone commits murder – that understands the meaning of it (around 8-10 y.o.), they should get the death penalty; or at least Life imprisonment, with NO possibilty for parole!
This will knock the murder rate by hundreds!“The second amendment is not absolute;”
I agree! We should amend the Constitution – that every adult must be armed, to prevent all this crime!
Sometimes we have to give up things we may enjoy (NO Weapons) for the betterment/safety of society.
Now I’m gonna repeat from Page 1, because n/o commented:
“Now let’s take the murder capital in the US – it’s E. St. Louis, Ill. I’m sure a lot of their murders are from guns. And a lot of them are perps under 21. So would your idea of Gun Control stop most killings in the USA?!? LIBERALS – Stop Dreaming!!!”March 4, 2018 5:47 pm at 5:47 pm in reply to: President Donald Trump, Oheiv Yisroel Par Excellence #1480672HealthParticipantCrazykanoiy -“Health, You can support Trump and still criticise him when critiscm is due. Why must you support and defend every disgusting and obnoxious thing he says.”
I support him when I feel he is right!
“His comments on Charlottesville were wrong and indefensible.”
I think his comments was very in the middle. If I would comment – they’d be much more on the right!
“Trump is not a great oheiv yisrael but rather a deeply flawed man who plays to peoples base instincts. Even Conservative hero Ben Shapiro criticized Trump at CPAC over his repulsive comments on Charlottesville”
Who’s B. Shapiro?!?
Did this guy also support Cruz or the guy from Florida? The real conservatives voted for Trump! We don’t want candidates that you libs can live with!!!March 4, 2018 11:50 am at 11:50 am in reply to: Donald Trump Is Bad And Has Popular Support #1480336HealthParticipantJoe -“How is Sunday different than Monday for a Yid?”
Stop with I’m Frummer than thou attitude!
If the guy works in the Goyish Velt – Sunday is an off-day.March 4, 2018 11:23 am at 11:23 am in reply to: President Donald Trump, Oheiv Yisroel Par Excellence #1480322HealthParticipantUbiq -“so think about it, how long does it take?”
Ok. Trump is right! Your assumption that e/o at that rally has to be a sympathyzer for Nazis is absurd!
Maybe these guys came to demonstrate first. Do you say the same thing about e/o at the left opposition rally – that they are all Commies or Commie sympathyzers?!?March 4, 2018 1:13 am at 1:13 am in reply to: President Donald Trump, Oheiv Yisroel Par Excellence #1480122HealthParticipantUbiq -“anybody attending a neo-nazi rally, who realizes he is at a neo-nazi rally and sticks around whther becasue he supports “states rights” likes their shiny bald heads or the refreshments the yare serving, is not a very fine person.”
I personally haven’t thought into it. But the President is entitled to his opinon!
“Yes that is precisely the issue. do you not know what “glorification” means? it is treating him like a hero”
Look they did it a long time ago. Stop trying to dictate what people think – it’s called Freedom when you don’t police everything.
HealthParticipantMidwest2 -“They also called on lawmakers to “stop” (presumely) sale of guns to those under 21,…”
To all you emotional guys reaction to the Parkland School Shooting:
Let’s see – what do you want to accomplish? If it’s just to stop school shootings – then fine. But school shootings are far & inbetween in the US. The main issue is gun murder!
Now let’s take the murder capital in the US – it’s E. St. Louis, Ill. I’m sure a lot of their murders are from guns. And a lot of them are perps under 21. So would your idea of Gun Control stop most killings in the USA?!? LIBERALS – Stop Dreaming!!!March 2, 2018 1:51 pm at 1:51 pm in reply to: President Donald Trump, Oheiv Yisroel Par Excellence #1479904HealthParticipantUbiq -“Please explain to me why Trump saying that some neonazis are “very fine” was a an example of Trump being nice”
Funny, but you have no problem why Trump was saying that some commies are “very fine” as a an example of Trump being nice; about BLM & their left buddies?!?
“Putting up a statue of him in public square/park isnt just a historical reminder, it is a glorification.”
Stop with the Liberal Lies! The statue was put up in a time when Lee was a hero.
March 1, 2018 7:11 pm at 7:11 pm in reply to: President Donald Trump, Oheiv Yisroel Par Excellence #1479746HealthParticipantUbiq -“Well you arent a “very fine person””
Your so far on the liberal left – it’s hard to respond!
Trump was being nice by saying there were fine people on both sides.
There weren’t! And the worse side was the BLM & their left buddies. They were there for violence only.
And why did the town agree in the first place to remove the statue?!? This country doesn’t have any GUTS anymore!February 28, 2018 11:00 am at 11:00 am in reply to: President Donald Trump, Oheiv Yisroel Par Excellence #1479256HealthParticipantTo laskern & crazykanoi – Where were you 2 libs when Obama & Hillary did things that weren’t Pro-Judiaism?!?
February 28, 2018 11:00 am at 11:00 am in reply to: President Donald Trump, Oheiv Yisroel Par Excellence #1479243HealthParticipantcrazykanoi -“I guess your silly definition of a “true” oheiv yisrael is a man who said neo-Nazi marchers are fine people.”
I’ll repeat from the first page –
“STOP Spouting the so-called “Jewish” Leftist Agenda!”February 27, 2018 9:15 pm at 9:15 pm in reply to: President Donald Trump, Oheiv Yisroel Par Excellence #1479089HealthParticipantchiefshmerel -“ARE NEO-NAZIS “VERY FINE PEOPLE?!”
STOP Promoting the Leftist Liberal Lies – just to denigrate the President!
Here is his actual quote:
“I’m not putting anybody on a moral plane,” he said. “You had a group on one side and group on the other and they came at each other with clubs – there is another side, you can call them the left, that came violently attacking the other group. You had people that were very fine people on both sides.
Not all those people were neo-Nazis, not all those people were white supremacists. Many of those people were there to protest the taking down of the statue of Robert E Lee. So this week, it is Robert E Lee. I noticed that Stonewall Jackson is coming down. I wonder, is it George Washington next week? And is it Thomas Jefferson the week after? You know, you really do have to ask yourself, where does it stop?”February 26, 2018 6:22 pm at 6:22 pm in reply to: Are the nazis really descendants of Amalek #1477743HealthParticipantTakes2-2tango -“name can the Nazis ym be from amalek?”
This I don’t know, but the Megillah prophesized the outcome of the Nuremberg trial.
J. Streicher knew this also when the second before hanging – he screamed “PurimFest 1946”!
I googled that word and there is a book from France called “Code of Esther”.February 26, 2018 11:14 am at 11:14 am in reply to: Are the nazis really descendants of Amalek #1476954HealthParticipantHaLeivi -“Amaleq as a nation is gone since the days of Shaul Hamelech. Haman was an individual in Persia”
You’re sadly mistaken!
Haman was called Haman HaHagogi.
From JEWISH Encly…
“Haman was a direct descendant of Agag in the sixteenth generation and consequently an Amalekite (Targ. Sheni;etc.”February 25, 2018 9:41 pm at 9:41 pm in reply to: President Donald Trump, Oheiv Yisroel Par Excellence #1476716HealthParticipantlaskern -“Doesn’t white supremacy include anti-semitism?”
STOP Spouting the so-called “Jewish” Leftist Agenda!
From WikiPedia:
“Breitbart News was described by the Anti-Defamation League as “the premier website of the alt-right” representing “white nationalists and unabashed anti-Semites and racists.”[69] The Zionist Organization of America rejected accusations of anti-semitism, saying that Breitbart News instead “bravely fights against anti-Semitism” and called for the ADL to apologize.[70][71] An article in Jewish Daily Forward argued that Bannon and Andrew Breitbart are anti-Semitic.[72] An article by Rabbi Shmuley Boteach in The Hill disputed the allegations, arguing that Breitbart defends Israel against antisemitism.[73] Alexander Marlow denies that Breitbart is a “hate-site”, stating “that we’re consistently called anti-Semitic despite the fact that we are overwhelmingly staffed with Jews and are pro-Israel and pro-Jewish. That is fake news”February 25, 2018 1:48 pm at 1:48 pm in reply to: President Donald Trump, Oheiv Yisroel Par Excellence #1475951HealthParticipantlaskern – “Is that why he hired Banon as his advisor?”
Your implication that Bannon is an antisemite is FAKE News!February 25, 2018 1:48 pm at 1:48 pm in reply to: Is there any way to prevent mass shootings???? #1475945HealthParticipantUbiq -“though I’m not sure which question you are referring to”
This question:
“What do you agree with? That a lot of guns should be made illegal?!?”February 25, 2018 2:54 am at 2:54 am in reply to: Is there any way to prevent mass shootings???? #1475756HealthParticipantUbiq – “I am in complete agreement about that. LEts stand up to the NRA we can be two liberals aganist their evil movment. (they have iopposed all 3 of the measures you mention!!!!!”
I was agreeing with Trump; if Congress doesn’t go along – 2 people against the NRA is useless!
You still didn’t answer my question.February 23, 2018 10:04 am at 10:04 am in reply to: Is there any way to prevent mass shootings???? #1475440HealthParticipantUbiq – “Dont look in the mirror, but so do you.
and I quote: “I agree with Trump about making gun ownership more regulated””This is what I agree with – Trump tweeted this:
“I will be strongly pushing Comprehensive Background Checks with an emphasis on Mental Health. Raise age to 21 and end sale of Bump Stocks!”
What do you agree with? That a lot of guns should be made illegal?!?February 22, 2018 5:25 pm at 5:25 pm in reply to: Is there any way to prevent mass shootings???? #1475223HealthParticipantUbiq – “Health – “I agree with Trump about making gun ownership more regulated.”
Ah so we agree!”I’m not so sure. I’ve been under the impression, all these years, that you believe in gun control like all liberals!
February 22, 2018 12:16 pm at 12:16 pm in reply to: Is there any way to prevent mass shootings???? #1474244HealthParticipantUbiq -“Your posts are hard to follow and jump from topic to topic making any chain of logic (if there is one) difficult to follow. I’m tired of always having t o help things out and get things on track for you.”
Funny NOT one other poster has trouble following my posts!
“You make it even harder by not addressing direct questions.
We are talking about shootings and that it is “impossible to believe that there is no other solution,” I dont see how “yes but they have terrorism” (im paraphrasing) has anything to do with anything”OK. Again for those that didn’t get it the first time!
To protect against School Shootings – make them like courts, with armed guards & metal detectors.
I agree with Trump about making gun ownership more regulated.February 21, 2018 5:08 pm at 5:08 pm in reply to: Is there any way to prevent mass shootings???? #1473894HealthParticipantUbiq -“Yes and they have a lower infant mortality, but what does that have to do with anything?”
You obviously didn’t read my whole post! It was a continuation.
Here it is again:
“There is no country in the world as big as the US & as safe!
Even the small countries in Europe, with all their Gun Control, have a bigger problem with Terrorism than the US.”February 21, 2018 5:08 pm at 5:08 pm in reply to: Is there any way to prevent mass shootings???? #1473898HealthParticipantYidd23 -“I wouldn’t move to Europe, but not because of safety, but because I don’t speak the languages and can’t stand the accents.”
Stop being Dishonest!
How can you claim “not because of safety”, when you could learn the language of that country?!?
Once you learn the language & it becomes your primary language, you will have the same accents that you can’t stand NOW!February 21, 2018 12:17 pm at 12:17 pm in reply to: Is there any way to prevent mass shootings???? #1473668HealthParticipantYidd23 -“So even if gun control were absolutely known to stop mass shootings, you wouldn’t support it? If you love guns more than you care about people, that’s a problem in itself.”
Don’t put words into my mouth! Why don’t you move to Europe, it’s a lot Safer there, because of their Gun Control?!?
February 21, 2018 11:42 am at 11:42 am in reply to: Is there any way to prevent mass shootings???? #1473667HealthParticipantUbiq – “But it is impossible to believe that there is no other solution, when throughout the civilized world there is no need for schools to be protected that way”
Stop dreaming that the US can be some sort of utopia!
There is no country in the world as big as the US & as safe!
Even the small countries in Europe, with all their Gun Control, have a bigger problem with Terrorism than the US.February 20, 2018 6:16 pm at 6:16 pm in reply to: Is there any way to prevent mass shootings???? #1473273HealthParticipantUbiq – “So I just want to make sure I understand you correctly
“youre saying We have to accept that mass shootings are just a way of life in the US, and are worth it to avoid being “like Europe with their liberalism””
“Is this your position?”My position is – if there is another way to stop mass shootings besides gun control – I’d be for it.
I’d like to know why are the libs constantly screaming “Gun Control”, when there is a school shooting?!?
How come they aren’t protecting schools, like they do with Courts???February 20, 2018 11:04 am at 11:04 am in reply to: Is there any way to prevent mass shootings???? #1472703HealthParticipantMeno -“I’m pretty sure I read that the shooter entered the school through a back entrance. What good is an armed guard if there are other ways to get in?”
100% CORRECT!
My previous posts compared that schools should be like courts. In every court building, no matter how many entrances there are, e/o must go through security! That means metal detectors & armed guards.February 20, 2018 11:04 am at 11:04 am in reply to: Is there any way to prevent mass shootings???? #1472693HealthParticipantUbiq -“Just to be sure I understood you correctly, youre saying We have to accept that mass shootings are just a way of life in the US, (“is-there-any-way-to-prevent-mass-shootings…And the answer …is NO!”) and are worth it to avoid being “like Europe with their liberalism””
The topic of these posts I presumed was about schools shootings. But my statements are correct!
Europe is Much Worse than here with their constant threat of Terrorism!February 20, 2018 5:40 am at 5:40 am in reply to: Is there any way to prevent mass shootings???? #1472526HealthParticipantUbiq -“Oops wrong again. The school in question had an armed security card, as you may know it dint stop the attack”
You have to read my whole post before commenting! I wrote -“All you need is one armed security guard & a metal detector.” The word “and” is not instead of “or”!
“Mass shootings are not a part of life in other countries as they are here. There has to be a way to be more like them in this regard”
Your obsession with Gun control didn’t let you begin to understand my point!
We don’t need to be like Europe with their liberalism to the Nth degree!
Go visit a court house and try to bring in a weapon.
Every school should be like courts with their tight security!edited
February 19, 2018 4:34 pm at 4:34 pm in reply to: Is there any way to prevent mass shootings???? #1472109HealthParticipantFF -“is-there-any-way-to-prevent-mass-shootings”
The title of your topic is disingenuous! It sounds like you belong to the “Gun control” people. You could have written – is there anyway to prevent mass bombings?
And the answer to both is NO!
But you could prevent school violence. All you need is one armed security guard & a metal detector.
I’ve been in court many times and they have Many armed guards and metal detectors.
I guess Americans care more about Judges & lawyers, than they do about school children!HealthParticipantGoldilocks – Why don’t you use wine? I once made a punch like that.
February 18, 2018 4:31 pm at 4:31 pm in reply to: Unhealthy lifestyle in the Frum community. #1471482HealthParticipantGamanit – “For those who don’t want to visit the site; it’s a joke.”
It could be that was their intention; but a lot of people didn’t take it that way. Eg. iacisrmma from above!
February 15, 2018 9:18 pm at 9:18 pm in reply to: Unhealthy lifestyle in the Frum community. #1470342HealthParticipantiacisrmma -“Have you seen the latest Oorahthon ad?”
I really didn’t notice it, but once you mentioned it – I decided to quote it:
“Oorah is proud to announce their latest fundraising campaign, Eat4Oorah. Join the campaign by committing to gain 5 pounds or more this Purim to help yiddishe kinderlach. With resources such as a helpful list of high-calorie foods, and support along the way, it’ll be easy to raise the requisite $1,800 to participate. Oorah suggests soliciting extra kokosh cake, brisket, and hamantashen from friends and family when you ask for sponsorships. So stop drooling and start eating, after all, it’s for the kinderlach.”
All I can say is WOW!!!February 15, 2018 6:44 pm at 6:44 pm in reply to: Unhealthy lifestyle in the Frum community. #1470232HealthParticipantAvram in MD -“Also, I think the ads you mention skew more towards younger people because their deaths R”L are usually unexpected, and therefore there is a higher chance that there wasn’t a completed plan of support for their dependents. I don’t think we can derive statistics from those ads. Also, the causes of death cited in those ads tend to be things like cancer or accidents, not obesity related disease.”
Your post is an example of typical ignorance! Cancer is sometimes due to an unhealthy lifestyle.
BTW, I was thinking about an ad where the deceased was obese!
This, along with smoking, is basically a non-issue in the Frum community.February 15, 2018 11:43 am at 11:43 am in reply to: Unhealthy lifestyle in the Frum community. #1469908HealthParticipantI noticed that every Jewish publication, including YWN, has ads collecting for tragedies. I never seen collecting when the victim is an older person. So unfortunately there are quite a few tragedies – some of which are preventable. It’s high time that this be acknowledged in the Frum community!
February 14, 2018 9:54 pm at 9:54 pm in reply to: Unhealthy lifestyle in the Frum community. #1469587HealthParticipantFYI -“Smoking is no longer the leading cause of preventable death in Americans, according to research presented at the 2017 Society of General Internal Medicine Annual Meeting this week.
The new culprit—obesity.
Researchers found that obesity dramatically beat out other leading causes of preventable death, including diabetes, tobacco use, high blood pressure and high cholesterol. After examining how these modifiable risk factors were linked to causes of death, they determined that obesity caused 47 percent more life years lost than tobacco.”February 13, 2018 4:24 pm at 4:24 pm in reply to: Unhealthy lifestyle in the Frum community. #1468728HealthParticipantShopping613 -“Unhealthy liftstyle exists everywhere.”
That’s true, but the Goyim don’t have the Chiyuv of Vinishmarten etc.!
February 13, 2018 4:23 pm at 4:23 pm in reply to: Unhealthy lifestyle in the Frum community. #1468725HealthParticipantMindful – Thank you for your comment. The other posters are regular posters & they think that they must disagree with anyone who posts!
HealthParticipantjakob -“What is your honest opinion? do you even realize how bad the situation is getting?”
I believe that the DemonCrats are worse than Communist Russia! I believe that there was a vast conspiracy to defame Trump & to push Hillary into the Presidency.
HealthParticipantYidd23 – “Health, your healthcare degree doesn’t count if you don’t show it or at least specify it in some way. For all we know, you could be a veterinary psychiatrist”
I could be.
You have’t proved you have Semicha to call yourself “Reb”!HealthParticipantWtP – ” quite offended that you call me a hypochondriac”
The reason is you should Trust in Hashem that the antibiotics will get rid of the PANDAS; if indeed it’s there. That’s the reason of my labeling.
In my opinion, this case would benefit from CBT & at least SSRI’s!HealthParticipantPANDASDad – “Since I have gone though a lot of this”
Which ones have you done?
Have you done CBT and SSRI’s or other psychiatric medications?“Many do steroid bursts, IVIG and plasmaphersis. (I have gone though all with my son). Some then go on to an immunosuppressant if that above doesn’t ”
It doesn’t sound like you’re a medical professional because you first say steroid bursts & then immunosuppressant. In my mind steroids are given as an immunosuppressant!
HealthParticipantWtP -“Health, yes.”
OK, That’s what I thought. This isn’t a freebie anymore – find me a Shidduch.
You are a hypochondriac. It does’t matter if it’s PANDAS or not!
Btw, I feel bad for DrMamaBear, but you aren’t HER!
From above -“initial first-line agent (oral penicillin, benzathine penicillin, or a first-generation cephalosporin) is reasonable. When multiple recurrences are believed to be due to GABHS infection, clindamycin or amoxicillin/clavulanic acid is indicated. [1]”
In practice, the majority of children with recent-onset PANDAS experience a reduction in neuropsychiatric symptoms within days or weeks after antimicrobial treatment active against acute GAS infection”
Azithromycin is NOT recommended!
Also, all family members should be tested to see if they are carriers.HealthParticipantWtP -“By the way, the antibiotics of choice – azithromycin- is believed to be effective not only because it kills the strep bacteria, ”
Maybe I didn’t understand your post. Is the kid on Azithromycin or not?
HealthParticipantDY -“Healrh, WTP is in touch with “a practitioner who is up on the latest research- who actually is part of the latest research”, and you insist on copy/pasting from a website?”
Your post is laughable if not for the issue of life & death!
I’m sorry that you never heard of Emedicine from Medscape.
Here’s from the actual guys who made decisions about PANDAS:
From the PANS/PANDAS Consortium:
“Clinical Management of Pediatric Acute-Onset Neuropsychiatric Syndrome: Part III—Treatment and Protocol
Throat swab
A throat swab for GAS is recommended during the initial diagnostic evaluation for PANS, particularly if the child is not already receiving antistreptococcal treatment. Testing for GAS is recommended regardless of the presence of clinical pharyngitis or the severity of neuropsychiatric symptoms at that time. A throat swab should also be performed both during exacerbations of neuropsychiatric symptoms and during episodes of pharyngitis, particularly in children not receiving an appropriate antibiotic, or if adherence to the prophylactic regimen is in doubt. Perineal and other extra-oral sites should be inspected routinely, with cultures obtained from suspected infection sites.
The throat of asymptomatic family members and other intimate contacts should also be swabbed, if possible, at the time of initial diagnosis, and at any time they have pharyngitis symptoms. When patients have PANS exacerbations, untreated close contacts should be questioned about symptoms of pharyngitis or dermatitis, and cultured and treated if positive.
Management of Streptococcal Infections in PANDAS
Primary antimicrobial treatment of acute streptococcal infections
Primary antimicrobial treatment for all patients with pharyngeal GAS is indicated, with oral or intramuscular penicillin as a first choice (Gerber et al. 2009). In current practice, amoxicillin is often used in suspension form for younger children due to its enhanced palatability (American Academy of Pediatrics 2015a). Injectable antibiotic therapy is considered the most reliable, although in practice it is usually reserved for children failing or unable to accept oral therapy. The objective of antimicrobial therapy of acute streptococcal infection is to eradicate the current GAS infection to minimize non-suppurative sequelae such as rheumatic fever (Shulman et al. 2012).
For children allergic to, or intolerant of, penicillin, cephalexin, cefadroxil, clindamycin, azithromycin, or clarithromycin are recommended according to the IDSA 2012 guideline for the treatment of acute GAS pharyngitis (Shulman et al. 2012) (Table 2). Children with persistent or rapidly relapsing pharyngitis may also be treated with these agents, which may be more effective clinically than penicillin or amoxicillin (Casey et al. 2008).
Table 2. Antimicrobial Treatment of Acute Streptococcal Pharyngitis
The use of azithromycin as an alternative for the treatment of pharyngeal GAS infection may be less efficacious, due to regional GAS resistance rates as high as 5%–10% or more (Silva-Costa et al. 2015) with an associated potential for the development of sequelae (Logan et al. 2012). Theoretical advantages of azithromycin include its ease of administration, its activity against most Mycoplasma pneumoniae, and its potential immunomodulatory (Obregon et al. 2012) activities. Disadvantages include its potential to promote azithromycin resistance of both GAS and M. pneumoniae. The U.S. Food and Drug Administration recommends that it be used with caution in patients with a prolonged QT interval on the electrocardiogram, and may be contraindicated in patients receiving medications that prolong the QT interval, which includes some of the selective serotonin receptor inhibitors (SSRIs), as well as anti-psychotic medications and other psychoactive drugs.
The use of oral clindamycin suspension may be problematic in children due to its unfavorable taste. Recent data suggest that clindamycin resistance may also be emerging, albeit at a lower frequency than azithromycin, in North America and worldwide (Villaseñor-Sierra et al. 2012; O’Dwyer et al. 2013), notably appearing in localized outbreaks of specific GAS emm types (Smit et al. 2015). Also of concern, clindamycin appears to disturb the protective throat and fecal microbiome to a much greater and a more prolonged degree than other commonly used oral antimicrobial agents (Zaura et al. 2015).
For children allergic or intolerant to the penicillins, the Consortium preference favors cephalexin (bid or tid) or cefadroxil (once daily), in the absence of immediate-type hypersensitivity to penicillin. Among patients with confirmed amoxicillin hypersensitivity, there is a particular cross-allergenicity with cefadroxil, which, unlike cephalexin, shares an identical R side chain with amoxicillin (Miranda et al. 1996; Sastre et al. 1996); cephalexin may, therefore, be preferred in this setting. Some investigators provide this initial treatment for 3 weeks, awaiting resolution of neuropsychiatric symptoms.
Treatment of GAS in children with PANS or PANDAS
With a new diagnosis of PANS, it has been our practice to provide an initial course of antimicrobial treatment for acute streptococcal infection as described earlier, regardless of whether or not GAS is identified at the time of diagnosis, similar to recommendations for the initial management of rheumatic fever (Gerber et al. 2009). Although data from controlled clinical trials are lacking, aggressive diagnosis and treatment of GAS infection seems prudent as a means of mitigating risk for neuronal injury. In practice, the majority of children with recent-onset PANDAS experience a reduction in neuropsychiatric symptoms within days or weeks after antimicrobial treatment active against acute GAS infection (Murphy and Pichichero 2002; Murphy et al. 2004; Snider et al. 2005; Falcini et al. 2013).
Table 3. Management of Infection in PANDAS
Secondary antimicrobial prophylaxis for children with PANDAS
There is currently insufficient evidence to support long-term streptococcal prophylaxis for children with PANDAS. To this end, members of the Consortium commonly institute long-term streptococcal prophylaxis for the most severely affected children, and for those with multiple GAS-associated neuropsychiatric exacerbations. The rationale for using secondary prophylactic measures is to prevent recurrences of intolerable, debilitating symptoms, as well as to minimize the possible risk of long-term sequelae or chronic symptoms. Weighing these theoretical benefits against the known risks of long-term antibiotic administration requires a careful consideration of the patient’s history and clinical status. We believe that the decision to institute long-term antimicrobial prophylaxis may best be made in consultation with a pediatric infectious diseases specialist, or a member of the PANS/PANDAS Clinical Research Consortium. When secondary GAS prevention is chosen, the antimicrobial regimens should be based on guidelines developed for the prevention of rheumatic fever.”HealthParticipantWtP -“Anyway, he is also very anti-meds, and his suspicion about long-term use of antibiotics stems from a close relative of his who was treated that way for rheumatic fever and suffered bad side effects- so since PANDAS is associated with long-term antibiotics, he doesn’t want to hear it.”
Just sometimes you should listen to your husband!
HealthParticipantWtP – “The issue is how long to continue the antibiotics- the protocol I got from a practitioner who is up on the latest research- who actually is part of the latest research – is to continue until symptoms subside and then slowly taper the dose.”
BALONEY!!!
This is from Emedicine about Pharyngitis due to Strep.:
“Circumstances dictating that a choice other than penicillin V should be used
Compliance: Oral penicillin requires multiple daily doses and a 10-day course. In patients unlikely to adhere to this regimen, one dose of intramuscular benzathine penicillin provides a depot that releases medication over the course. Recent reports have supported the use of once-daily amoxicillin and verified its noninferiority to twice-daily penicillin [44] or twice-daily amoxicillin. [45] Azithromycin, cefdinir, and cefpodoxime may all be given in 5-day courses, although none of these medications should not be considered a first-line agent given their extended spectrum and risk for promoting antibiotic resistance. [1, 48, 49] Furthermore, although no differences in treatment outcomes have been found between macrolides and penicillin, children experienced more adverse events with macrolides. [47]
Palatability: Some young children find oral penicillin unpalatable. Taste tests and many doctors’ experiences have shown amoxicillin to be much better tolerated. [50] Amoxicillin’s similar spectrum and low cost make it a reasonable substitute.Recurrence: Test of cure is not indicated when pharyngitis symptoms have resolved following treatment. In patients with recurrent symptoms, retreatment with an initial first-line agent (oral penicillin, benzathine penicillin, or a first-generation cephalosporin) is reasonable. Worth noting is the difficulty in differentiating between viral pharyngitis with GABHS carriage and actual GABHS pharyngitis. This becomes even more of an issue in patients with multiple recurrences. Between 5% and 15% of children are asymptomatic carriers during seasons when GABHS pharyngitis is most prevalent. [55] A positive test result during a time of wellness may indicate GABHS carriage. When multiple recurrences are believed to be due to GABHS infection, clindamycin or amoxicillin/clavulanic acid is indicated. [1]”
-
AuthorPosts