When faced with the question of transplant and whether or not donating is what Hashem wants from us what WE personally decided was to go ahead and try (with a sense of commitment). We wanted to do it and figured (on our basic level of emunah) that if it is not what Hashem wants from us then one of the hundreds of things that would disqualify us would be present. We could know we did our hishtadlus, know we get the mitzvah for our intent and thats the end of it. When we ended up a match we felt that perhaps that was an indication that that was what Hashem wanted from us. Of course we spoke to our Rav, (and our kids, but not for a psak) but it helped give us direction. Instead of sitting and making decisions about things that may not even be shiach, we tried to see if we could get hints from Hashem and take each step as it came.
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