First of all good luck to him. The most important thing is to remember that entering the workplace can be hard and having a supportive wife will help *A LOT*.
I can’t tell him what the right job for him is, I don’t know you or him. But here are some ideas:
Check out Dan Miller’s book “48 Days to the Work you Love” and Maybe “No More Mondays”. You will want to read them carefully and probably make lots of notes.
Also remember that the more debt you have the more risk, so minimize both!