Tam
I would say simcha must come from within. True simcha comes when a person is living how they should and is close to Hashem. Sadness or depression comes from sin and from the sadness of the neshama that its being put through such spiritual torture.
Simcha is the result of working on oneself and changing and growing. Stimulants don’t provide simcha. That’s not simcha that’s sillyness, giddiness, hyperness, hallucinatory…
Simcha doesn’t mean you smile all day btw. Its a general state of happiness with who you are and where you are going with your life.