Pope Francis was in critical condition Saturday after he suffered a prolonged asthmatic respiratory crisis while being treated for pneumonia and a complex lung infection, the Vatican said.

The 88-year-old pope, who remains conscious, received “high flows” of oxygen to help him breathe. He also received blood transfusions after tests showed low counts of platelets, which are needed for clotting, the Vatican said in a late update.

“The Popes condition continues to be critical, therefore, as explained yesterday (Friday), the pope is not out of danger,” the statement said. It was the first time “critical” had been used in a written statement to describe Francis’ condition since he was hospitalized Feb. 14.

The statement also said that the pontiff “continues to be alert and spent the day in an armchair although in more pain than yesterday.” Doctors declined to offer a prognosis, saying it was “reserved.”

Doctors have said Francis’ condition is touch-and-go, given his age, fragility and pre-existing lung disease.

They have warned that the main threat facing Francis would be the onset of sepsis, a serious infection of the blood that can occur as a complication of pneumonia. As of Friday, there was no evidence of any sepsis, and Francis was responding to the various drugs he is taking, the pope’s medical team said in their first in-depth update on the pope’s condition.

Francis, who has chronic lung disease and is prone to bronchitis in winter, was admitted to Gemelli hospital on Feb. 14 after a weeklong bout of bronchitis worsened.

Meanwhile, the Vatican hierarchy went on the defensive to tamp down rumors and speculation that Francis might decide to resign. There is no provision in canon law for what to do if a pope becomes incapacitated. Francis has said that he has written a letter of resignation that would be invoked if he were medically incapable of making such a decision. The pope remains fully conscious, alert, eating and working.

The Vatican secretary of state, Cardinal Pietro Parolin, gave a rare interview to Corriere della Sera to respond to speculation and rumors about a possible resignation. It came after the Vatican issued an unusual and official denial of an Italian media report that said Parolin and the pope’s chief canonist had visited Francis in the hospital in secret. Given the canonical requirements to make a resignation legitimate, the implications of such a meeting were significant, but the Vatican flat-out denied that any such meeting occurred.

Parolin said such speculation seemed “useless” when what really mattered was the health of Francis, his recovery and return to the Vatican.

“On the other hand, I think it is quite normal that in these situations uncontrolled rumors can spread or some misplaced comment is uttered. It is certainly not the first time it has happened,” Parolin was quoted as saying. “However, I don’t think there is any particular movement, and so far I haven’t heard anything like that.”

(AP)