It says in Derech Mitzvosecha each yid has a role as a body part in klal yisrael. Sinas Chinam causes a yid to spiritually cut himself off from having the body part he hates, effectively creating a spiritual mum in himself. Just like a Korban wasn’t accepted by a kohen doing the avodah with a mum, when someone who holds baseless hatred in his heart for another yid has his davening rejected.
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