Nothing is certain. It should be noted that most Israelis are willing to fight for their survival, and most Americans are either “Reagan Republicans” or “John Kennedy/Harry Truman Democrats” (albeit in different parties) rather than MAGA or WOKE.
Trump may turn out to using the threat of isolationism to encourage allies to get ready for war, and may then announce that what makes America great is leading the free world. Iranian reliance on American disinterest or incompetence will soon turn to fear (China and Russia will decide against invading their neighbors)
The Democrats can decide to tell the “Progressive” (WOKE, and anti-Semitic, among other things) caucus to bug off – or if the Democrats turn left, while Trump stays isolationist, it will create an opening for a third party that will be globalist and not anti-Jewish. Either well the non-Trump party will also favor a strong military response to the Sino-Russian axis (which includes Iran and its clients).
The Israelis could get their act together and be able to defeat their enemies without foreign aid – it would be messy and require the Israeli elite (secular, left, 1st world standard of living) to accept that they live in a third world country dominated by non-secular, non-Europeans, and a standard of living similar to the 1950s – but Israel could be militarily self-sufficient which the capability of deterring its enemies. If Israel could take out Iran, and neutralize Hamas and Hezbollah (which are Iranian clients), it would the from a position of strength attempt to negotiate with the Palestinians (who are the only Arabs who matter if Israeli wants to survive).
Or the Zionists will go down in Jewish history along with Shabatai Zvi, has one very bad idea with disastrous results. The Hareidim will survive, as we always do, but most of the non-religious Jews (who outside of Israel have minimal birthrates already) will disappear. The best remembered Jewish leader of this era will be the original Satmar Rebbe, and people such as Herzl, Ben Gurion, and Netanyahu will be known only by historians interested in obscure tangents.