There are some genes that apparently are only found among certain groups, so if one has American (i.e. Indian, indigenous) ancestry it would be obvious. The trick is to be from a very isolated group (the Americans were almost totally cut off from the rest of humanity before the 16th century, the Australians before the 19th, and most Africans until the late 19th century). However in the bulk of Eurasia people moved around a great deal whether as conquerors or merchants, so genes are more mixed up, e.g. the “Middle Eastern” gene found in England could have come from a Jew, or perhaps a Cartheginian slave owned by a Roman, or from a Roman soldier recruited in the Middle East who stayed in England when discharged.
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