Any time there are people present for whom there is not a problem of Yichud, there is no problem for anyone else who is there. Since the brother and sister are allowed to be together, there is no problem for the second man either.
Mr. Clean is definitely a Parutz. I believe the same is true for Cap’n Crunch. I don’t know about Granny Smith, but it’s a moot point since she’s a woman.
Gefen and Manischewitz, though, should be ok (as long as they’re both present).