sure. I remember having a big problem on a flight to EY once. I had a window seat next to a super-annoying not-Jewish older lady whom I had to keep asking to move everytime I had to use the b.r, so I really tried to limit the amount of times I got up.
I was quite offended when she made a comment about how often I used the ladies’ room on the flight! I thought 3 times for a 10 hour trip was pretty good!
Anyhow, I was super-uncomfortable asking her to move so I could wash negelvasser, so I wasn’t sure what to do, and I didn’t know the halachos at the time, so I think I really messed up both with washing negelvasser and brachos.
The point is that it is good you are asking someone even if the CR isn’t the best choice, because once you are on the flight you might not have anyone to ask, and there are a lot of sheilahs that come up on planes.