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Well, yes there is always a stimulus. There is also a stimulus to catching any disease – going where the various germs are. And just like the stimulus for any other disease causes (we’re at those words again) BIOLOGICAL and PHYSICAL changes in the body – bacterial or viral cells and organisms to wreak havoc, So too do the stimuli for depression cause (here we go) BIOLOGICAL and PHYSICAL changes through chemical imbalance. But it’s impossible to eliminate the stimuli that cause depression, the same way we can’t really completely prevent ourselves from getting sick. You generally can’t prevent the loss of a family member, or physical or sexual abuse from happening, can you? The stimuli that cause depression – various incidents that can cause grief, will not be eliminated from life, although we’d all love to avoid them. They are part of life. But not everyone gets depression either. Certain people can be biologically more likely to get it. So you treat depression with things that work – therapy or drugs (often both).