There is no Mitzvah to be really drunk. To drink more than usual, yes. To bring ourselves down to the level of Mamash (real) drunkenness, no. We are never commanded to degrade ourselves. We see early on in the history of man the degradation that comes from drunkenness – Noah and Lot. The Rabbis would never ask us to stoop to that level.
At that level we lose the form of being human and are completely cut off from any holiness. For example, tznius does not apply to cows.
And during times when high fences against sin are needed, then even social drinking even on Purim needs to be curtailed. Only when high fences against sin are needed do we need to consider discouraging women from dressing up in costumes on Purim.